Biomedical and Therapeutics Letters
Keywords: item categories
Section: Biomedical Sciences
Keywords: Profenofos, reproductive toxicity, oxidative stress, sperm parameters, endocrine disruption, albino rats
The widespread use of the organophosphate insecticide profenofos in agriculture has sparked worries about its possible harmful effects on the reproductive system of mammals. This study set out to evaluate the consequences of everyday exposure to 25 and 50 mg/kg body weight of profenofos on the reproductive system of albino male rats. A low dose of 25 mg per kg, a high dose of 50 mg per kg, and no therapy were administered to three groups of adult male albino rats for a duration of forty-five days. The results revealed a significant dose-dependent decrease in sperm viability, motility, and count, as well as an increase in sperm abnormalities. These results show that male reproductive health is severely harmed by profenofos, which may result in infertility. In order to reduce the hazards of profenofos’ reproductive toxicity to mammals, the study emphasizes the necessity of stringent regulation and prudence around its usage.
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