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Bromelain: Targeting dental biofilm through dual approach of protein interaction and in vitro validation
Journal of Integrated Science and Technology Read More Keywords: item categories Bromelain, a proteolytic enzyme isolated from pineapple, is renowned for its therapeutic applications. The present work was designed to investigate the anti-microbial potential of bromelain against dental plaque-causing microbes via in silico and in vitro studies. Firstly, in silico study was conducted where docking…
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Stress response in biofilm forming Methicillin-resistant Staphylococcus aureus
Journal of Integrated Science and Technology Read More Keywords: item categories Staphylococcus aureus, especially methicillin-resistant strains (MRSA), represents a major global health concern due to its persistence, biofilm formation, and resistance mechanisms, with stress response pathways such as sigma B (sigB) playing a pivotal role in adaptation; however, their influence on biofilm dynamics and resistance…
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Green synthesis of cerium oxide nanoparticles using Prosopis cineraria leaf extract: Biomedical and environmental studies for multifaceted applications
Materials NanoScience Read More Keywords: item categories In this study, cerium oxide nanoparticles (CeO2 NPs) were synthesized through a green and sustainable route, utilizing Prosopis cineraria leaf extract as both the reducing and stabilizing agent. The synthesized CeO2 NPs were characterized using UV-vis spectroscopy, FTIR, XRD, SEM, EDX, TGA, DSC, DLS, and Zeta potential studies…
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Effect of the pH and heat on the stability and spectral properties of mercury (II) and copper (II) azo complexes
Journal of Integrated Science and Technology Read More Keywords: item categories In this study, complexes of mercury(II) and copper(II) were prepared with azo ligand (LA). The metal complexes were characterized by infrared spectroscopy, flame atomic absorption, measurements of magnetic susceptibility, continuous change and thermal analysis. Through the results, the complexes have a four-coordination geometric shape…
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From bench to bedside: A roadmap to emerging TB therapeutics
Chemical Biology Letters Read More Keywords: item categories Tuberculosis (TB) has persistently posed a formidable challenge throughout human history as a contagious disease. Despite the gravity of the global TB burden, the advancement of available therapeutic treatment has been minimal over several decades. The emergence of drug-resistant M. tb has diminished the efficacy of existing…
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Navigating Your PhD Viva: Tips for a Confident Defense
Navigating Your PhD Exam with Confidence The PhD defense, or viva, is not just an academic formality—it is the defining moment where you defend your research, demonstrate mastery, and position yourself as an independent scholar. To succeed, you must not only know your thesis inside-out but also present it with clarity, confidence, and scholarly maturity.…
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Optimization of BLDC motor speed controller for improving travel range of EV
Journal of Integrated Science and Technology Read More Keywords: item categories The BLDC motors are widely adopted in electric two wheelers and three wheelers. These motors exhibit excellent electrical and mechanical characteristics in lightweight electric vehicles. The speed control methods of BLDC motor are categorized as scalar and vector control methods. The scalar methods like…
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2-Styrylquinoline and its derivatives: Study of medicinal, electronic and spectral properties using density functional theory
Journal of Integrated Science and Technology Read More Keywords: item categories 2-Styryl quinoline ((M1) C17H13N) is biologically active compound that has various medical, optical and electronic applications. A density functional theory (DFT), and the B3LYP/6-311+G basis set were used to study the electronic, vibrational, and nonlinear optical properties of 2-styryl quinoline and it derivatives, ((M2)…
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Evaluation of synergistic antibacterial activity and cytotoxicity of [W4KR5]-Curcumin conjugates against drug-resistant pathogens
Chemical Biology Letters Read More Keywords: item categories The rise of antibiotic resistance necessitates new treatment strategies. Although curcumin exhibits antibacterial properties, its poor solubility and bioavailability limit its therapeutic use. This study investigates the antibacterial potential of cyclic peptide [W4KR5], curcumin derivatives, and their new conjugates to overcome curcumin’s limitations. Minimum inhibitory concentration (MIC)…
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Strain-promoted Azide-Alkyne cycloaddition: Cyclooctyne’s potential in revolutionizing therapeutic and diagnostic applications through bio-orthogonal reactions
Journal of Molecular Chemistry Read More Keywords: item categories Strain-promoted azide–alkyne cycloaddition (SPAAC) with cyclooctyne derivatives has become a valuable tool in bio-orthogonal chemistry, enabling highly selective and efficient bioconjugation without the need for toxic copper catalysts. The intrinsic ring strain in cyclooctynes (~18 kcal mol⁻¹) drives rapid triazole formation under physiological conditions, making these…
