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Prognostic implications of MDM2 and CDK4 co-amplification in Liposarcoma: Insights from FISH analysis for translational oncology
Integrated Research Advances Read More Keywords: item categories Introduction: Cancer, a widely prevalent disease, is impacted by various factors including genetics in its origin, propagation, diagnosis, control and therapeutics development. MDM2 and CDK4 are frequently amplified genes in liposarcoma, particularly in atypical lipomatous tumour/well-differentiated liposarcoma (ALT/WDLS) and dedifferentiated liposarcoma (DDLS). Although the oncogenic roles of…
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Study of in vivo immunomodulatory and in vitro anticancer effects in Convolvulus pluricaulis, Michelia champaca and Chromolaena odorata and in vivo nephroprotective activity in Pithecellobium dulce
Integrated Research Advances Read More Keywords: item categories Background: Evaluation of preclinical immunomodulatory anticancer models are very crucial in the process of drug discovery and development. Dysfunctional immune system is linked with disorders like autoimmune diseases, inflammatory diseases, cancer and as a treatment immunosuppressive or immunostimulant drugs are prescribed aiming at immune system disease. Synthetic…
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Combination therapy employing elastin nanogel for the treatment of Castration-Resistant Prostate Cancer (CRPC)- An in vivo mouse xenograft model investigation
Integrated Research Advances Read More Keywords: item categories Prostate cancer (PC) is the most prevalent cancer among men and ranks as the third leading cause of cancer-related mortality. Despite significant progress in the detection and localized treatment of prostate cancer, between 23% and 40% of patients may eventually develop metastatic disease. Castration-Resistant Prostate Cancer (CRPC)…
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Neuroprotective and anti-Parkinson effects of L-Carnosine in Rotenone-induced diseased model rat
Integrated Research Advances Read More Keywords: item categories Neurodegenerative disorders are the leading causes of human disability at present time and Parkinson Disease (PD) is one of the most common and fastest-growing one. Though it is a progressive disease, the current regimen is inefficient to halt the disease progression and underlying molecular dysfunction. The purpose…
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Parental attitudes on Autism Spectrum Disorder development among children in Malaysia: A review
Integrated Research Advances Read More Keywords: item categories Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that has been increasingly recognized worldwide, including in Malaysia. However, there remains a gap in understanding the prevalence, parental attitudes, cultural influences, and the role of knowledge and awareness in shaping societal acceptance of ASD. This review aims to…
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Molecular innovations in Plastic fuel toward a sustainable energy future and waste mitigationJournal of Integrated Science and Technology
Environmental Science, Plastic waste, Bioenergy, Biofuel production, Gasification, Pyrolysis The global issue of plastic waste (PW) presents a persistent environmental challenge, necessitating the adoption of effective and sustainable new mitigation strategies. One promising approach involves converting plastic waste into fuel, which not only alleviates the burden of waste management but also offers a more environmentally…
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Advanced predictive analytics with synthetic data: A comprehensive machine learning approach for predicting chronic and lifestyle diseasesJournal of Integrated Science and Technology
Engineering, Artificial Intelligence, Chronic, AI in Healthcare, Disease prediction, Random Forest Classifier, Gradient boosting With advancements in technology, artificial intelligence has become a breakthrough in the biomedical field and healthcare management. Chronic and lifestyle diseases are difficult to predict, primarily because of the multifactorial environment in which various risks and health consequences interact. The integration…
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Yttrium incorporation into the tungsten telluride (Y:WTe2) matrix achieved using three electrode systems.Materials NanoScience
Materials Science The three-electrode electrochemical deposition technique was used to synthesize Y:WTe2. With a molar concentration of 0.1 mol/g, tellurium dioxide acts as the precursor of zinc tungstate. The molar concentration of the dopant yttrium (III) nitrate hexahydrate ranges from 0.01 to 0.03 mol/g. The XRD patterns of WTe2 and yttrium-doped tungsten telluride material both…
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2-Deoxy-D-Glucose: A Promising Agent ifor Treatment of Cancer, Inflammation, and Viral Infections
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Polymeric Innovations Driving Sensitivity in Electrochemical Analysis
Section: Reviews Categories: Goal 3 Good Health and Well-Being, Goal 6 Clean Water and Sanitation, Goal 12 Responsible Consumption and Production, Goal 13 Climate Action, Goal 14 Life Below Water Keywords: Azulene (PZ), polypyrrole (PPy), polyaniline (PANI), polythiophene (PTh), poly (3,4-ethylenedioxythiophene) (PEDOT), polyactylene (PA) One significant family of organic functional materials is conducting polymers (CPs).…