Synthesis, spectral characterisation and biological evaluation of tridentate incorporated isoniazid Schiff base metal complexes​

Biomedical and Therapeutics Letters

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Section: Medical Biotechnology Biochemistry and Microbiology
Keywords: Synthesis, Schiff bases , Metal complexes, Antimicrobial activity, Antioxidant activity

The tridentate Schiff base ligand results from reaction of isoniazid and substituted 2-hydroxybenzaldehyde and its series of eight metal complexes (C1-C8) Co(II), Ni(II), Cu(II) and Zn(II) were prepared by conventional stirring method. The structural features of synthesized metal complexes were confirmed by IR, UV, DTA-TGA, XRD and ESR spectroscopic techniques. From the data, it illustrate that ligand coordinates with metal ions in neutral form through -N, -O, -O donor atoms. All complexes have octahedral skeleton with different crystal system and P4₁/P4₃ and P₁ space group for C1 and C6 complexes. The TGA study revealed that prepared metal complexes are stable at room temperature and almost show loss of weight at high temperature. Further all synthesized complexes were evaluated for in-vitro antimicrobial activity against E. Coli, S. aureus, C. albicans and A. niger. The activity index of prepared complexes revealed good to moderate growth inhibitory activity against all tested pathogens. The metal complexes display excellent potent activity compared to ligand. The perception to this activity has been made on the basis of pharmacophore structure of metal complexes and the groups present in it.