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AI and Protein Design: Transforming Chemistry in 2024
The 2024 Nobel Prize in Chemistry celebrates breakthroughs in understanding and designing proteins, the essential molecular machines of life. David Baker, Demis Hassabis, and John Jumper have revolutionized our ability to decipher and manipulate these intricate structures, enabling vast potential for scientific and practical applications. Mastering Life’s Building Blocks Proteins are the versatile chemical tools…
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DNA strand displacement-based sensor for the detection of miRNA-141 in serum samplesChemical Biology Letters
Articles, miRNA detection, DNA strand displacement, Serum analysis, FAM-labeled nucleotides, fluorescence signal, cancer marker, cancer detection MicroRNA (miRNA) expression is commonly dysregulated in various diseases. Our aim was to develop a simple and sensitive fluorescence-based assay for detecting microRNA-141 (miR-141) activity using DNA strand displacement. In this approach, one strand of the DNA probe (P1)…
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Targeting Plasmodium falciparum: Synthesis and evaluation of Phthalimide-HEA derivativesChemical Biology Letters
Articles, Hydroxyethylamine, Phthalimide, Malaria, Molecular Docking, Synthesis We demonstrated a facile microwave-assisted synthesis of 16 novel phthalimide (Pht)-hydroxyethylamine (HEA)-based compounds isolated without tedious column chromatography. Among all the tested compounds, 3b, 3f, and 3h displayed 50% inhibitory concentration in the micromolar range (0.17 – 1.60 µM) against the Pf3D7 strain. Of particular note, compound 3f…
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Discovery of novel Quinazoline based Thiazolotriazole hybrids as potential EGFR inhibitor: Synthesis, anticancer evaluation and in silico studiesChemical Biology Letters
Articles, Quinazoline, Thiazolotriazole, Anticancer activity, EGFR Inhibitor, Molecular Docking Significant efforts have been made to design and synthesize novel series of quinazoline based thiazolotriazole analogues (8a-8n) and examined for their anticancer activity against two cancer cell lines (MCF-7 & A549). The in vitro anticancer activity assessment of these analogues against the EGFR tyrosine kinase revealed…
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Antimicrobial Peptides in Tuberculosis: Insights into the Immunomodulatory MechanismsChemical Biology Letters
Review Articles, Mycobacterium tuberculosis, Antimicrobial peptides, Anti-TB therapy, immunomodulation, anti-mycobacterial compounds Tuberculosis is a highly contagious airborne disease that remains one of the leading causes of mortality worldwide. In the era of an increasing rate of drug-resistant strains and other shortcomings of current anti-TB therapies, we promptly need new, effective treatments to combat tuberculosis. Antimicrobial…
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Uncovering the potential of Fatty Acid Binding Proteins for predicting radiation-induced gastrointestinal injuryChemical Biology Letters
Articles, Ionizing radiations, Biomarkers, Gastrointestine, Fatty Acid, Nuclear Medicine Gastrointestine (GI) depression is a severe complication identified in individuals after intentional or unintentional radiation exposure. Early detection of radiation-induced GI injury (RIGI) is important for medical management with supportive care, which can largely be achieved using organ specific biomarkers. Fatty Acid Binding Proteins (FABPs) are…
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Investigating the effect of calcitonin gene-related peptide antagonist and exercise trainings in rat aorta: Mitophagy, mitochondrial biogenesis, and apoptosisChemical Biology Letters
Articles, mitochondrial dynamics, CGRP antagonist, Calcitonin Gene Related Peptide, cardiovascular system, Olcegepant, neuronal nitric oxide synthase, gamma coactivator 1-alpha Calcitonin Gene Related Peptide (CGRP) is expressed in the cardiovascular system and showed vasodilatory effects. This study aimed to investigate the effects of exercise training and a CGRP antagonist (CGRPi) on the expression of genes involved…
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Beyond trial and error: Leveraging advanced software for Therapeutic discoveryChemical Biology Letters
Review Articles, Schrödinger, Discovery Studio, MOE, Therapeutic, Software, Molecular docking, molecular simulations, molecular dynamics Simulations, AutoDock, AutoDock Vina, Docking Procedure In drug discovery, efficiency and precision are crucial elements that play pivotal roles in saving lives, time, and financial resources while pursuing groundbreaking advancements. To aid this, commercial software platforms are explicitly crafted. These platforms…
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Unveiling the effect of Inflammatory Cytokines TNF-α, IL-6, and IL-1β in Breast Cancer prevalence and progressionChemical Biology Letters
Articles, Breast cancer, Cytokines, TNF-α, IL-6, IL6-1β, Estrogen, Progesterone, Human Epidermal Growth Factor-2 Breast cancer remains a leading cause of cancer-related morbidity and mortality among women globally. Breast cancer is the most diagnosed cancer in women. Metastasis is the primary cause of mortality for breast cancer patients. In Bihar, there are so many cases of…
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Mechanistic insight into the antistress potential of eugenol: Modulation of the monoaminergic system in chronic unpredictable stress zebrafish modelChemical Biology Letters
Articles, Stress, Anxiety, Eugenol, Dopamine, Serotonin, Neuroprotection, nervous system, Brain functions, Antioxidants The unwanted side effects associated with existing therapeutics against anxiety disorder warrants further preclinical investigations to discover new drug candidates. Herein, we report the anti-anxiety effect of Eugenol (EUG), a phytoconstituent, in chronic unpredictable stressed (CUS) model of zebrafish. The zebrafish were exposed…
