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Eukaryotic Translation Initiation Factor 6 links Calcium signaling with ribosome biogenesis and a complex ribosomopathyChemical Biology Letters
Articles, Calcineurin, Calcium signaling, Ribosome biogenesis, Phosphorylation, Dephosphorylation, Ribosome synthesis, Shwachman-Bodian-Diamond syndrome, Cellular pathway, Cell Biochemistry Eukaryotic translation initiation factor 6 (eIF6) is highly conserved from yeast to mammals. It is essential for 60S ribosome biogenesis (a nucleolar function). eIF6 also escorts nascent pre-60S from nucleus to cytoplasm for final maturation. eIF6 must then recycle…
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MH50/+/-: σ Aromatic ClusterJournal of Molecular Chemistry
Molecular Simulations, metal penthydrides, aromaticity simulations, sigma-aromaticity, metal hydrides, electron density of delocalized bonds, core orbital, theoretical chemistry, computational chemistry Aromaticity is one of the central concepts in chemistry. Herein, quantum chemical calculations have been carried out to search for σ aromatic metal pentahydrides of the general formula MH5– (M = Ni, Pd, Pt). All…
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Nanomaterials for Neurological Disorders: A contemporary perspective of present and future possibilities for cureMaterials NanoScience
Nanomedicine & Biomaterials, Nanomaterials, Blood-brain barrier, Therapeutics, Neurological ailments, Metal oxide nanoparticles Neurological disorders (NDs) are a major global health concern, leading to high mortality rates, as stated by the World Health Organization (WHO). These disorders affect the central and peripheral nervous systems, including the brain, spinal cord, cranial and peripheral nerves, neuromuscular junctions, and…
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Effect of Co-doped alkali earth metal Ca2+, Mg2+, Sr2+ ions on spectral parameter for rare earth, Pr(III)-2-Amino Benzothiazole doped system in micellar mediumMaterials NanoScience
Materials Science, Transition level, Interaction-parameters, Electronic-absorption spectra, aromatic heterocyclic ligand Electronic transition levels of Pr(III) lanthanide ion with aromatic heterocyclic ligand containing N,S,O atom i.e. Pr(III)-2AB system/complex have been determined by electronic spectra in micellar (TX-100) medium at 25°. Using the Gaussian curve, the half band (υ1/2) width, and energy expression have been determined, such…
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Pioglitazone and Ezetimibe combination improves Liver histopathology and biochemistry in experimental MASH modelsChemical Biology Letters
Articles, MASLD, MASH, Pioglitazone, Ezetimibe, Drug combination, steatohepatitis, Liver histopathology Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are common clinico-pathological conditions that affecting over 30% of adults worldwide. Insulin resistance and hepatic lipid accumulation constitute the metabolic foundation of MASLD/MASH. Although previous studies have shown limited efficacy of activation of single…
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Biological and electrochemical Sensor detection studies of ZrO2 wrapped by reduced Graphene Oxide nanocompositeMaterials NanoScience
Nanosensors, reduced graphene, Nanosensors, electrochemical performance, sensor studies, ZrO2 The present work reports synthesis of ZrO2 nanoparticles wrapped by reduced graphene doped (rGO) nanosheet through simple reflux method. The sample was characterized using XRD, FE-SEM, EDAX, FTIR, UV-Visible techniques. The optical bandgap was calculated using Tauc’s method and found to be ZrO2 and ZrO2/rGO are…
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Physicochemical behaviour of homoeopathic dilutions of ammonium carbonicum at ambient temperatures: Volumetric, ultrasonic and viscometric studyJournal of Molecular Chemistry
Inorganic and Physical Chemistry, Dilute solutions analysis, Homeopathic medicines, Ammonium carbonicum, Viscosity determination, Density analysis, viscometric study, Physicochemical behaviour The physicochemical behaviour of homoeopathic dilutions of ammonium carbonicum has been studied from the measurements of the densities, r, ultrasonic speeds, u and viscosities, h of pure ethanol control and 32 formulations of potencies of ammonium…
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Molecular Docking Studies of 3a,4-dihydro-3H- [1,3,2] oxazaphospholo [3,4-a]Indole-1-oxide derivatives for Anticancer activityJournal of Molecular Chemistry
Molecular Simulations, 3a,4-dihydro-3H-[1,3,2] oxazaphospholo[3,4-a]indole-1-oxide derivatives, Lipinski’s Rule of Five, In silico docking, K-Ras oncoprotein, Anticancer activity This study evaluates eight novel 3a,4-dihydro-3H-[1,3,2]oxazaphospholo[3,4-a]indole-1-oxide derivatives (1-8) for their potential as drug candidates. Lipinski’s Rule of Five and Topological Polar Surface Area (TPSA) analysis suggest favourable properties for drug-likeness, pharmacokinetics, and potentially high intestinal absorption with estimated absorption…
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Chemistry of Coenzyme F420 in EnvironmentJournal of Molecular Chemistry
Review Articles, Coenzyme F420, Methanogenesis, Methanotrophic archaea, Climate change, Global warming Coenzyme F420 is one of the ancient and rare coenzymes. The unique electrochemical properties of F420 are compared with the ubiquitous flavin coenzymes FMN (flavin mononucleotide), FAD (flavin adenine dinucleotide), and nicotinamide coenzyme NADP+ (nicotinamide adenine dinucleotide phosphate). The 7,8-didemethyl-8-hydroxy-5-deazaflavin core of F420 is…
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Extraction of caffeine and sodium benzoate from different brands of cold drinks available in marketJournal of Molecular Chemistry
Analytical Chemistry, Liquid-liquid extraction, Murexide test, FeCl3 test, Acid-alkalimetry titration, Toxicity analysis Caffeine is an alkaloid present in beverages and soft drinks that are available on the market. It belongs to the methylxanthine family. An acceptable daily intake (ADI) of caffeine is 0.4-1.4 mg/kg of body weight for adolescents (10-18 years). It has an instant…
