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Pyrazole derivatives affinity to Estrogen receptor Alpha for breast cancer treatment evaluation using molecular dockingJournal of Molecular Chemistry
Medicinal Chemistry, Breast cancer, Molecular docking, Estrogen Receptor Alpha, Pyrazole, Heterocyclic drugs, Molegro Virtual Docker After lung cancer, which is the most common cancer overall, breast cancer is the second most common cancer in women. Breast cancer is primarily brought on by 17-estradiol, a key estrogen involved in cell initiation and proliferation and whose effects…
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Molecular docking and dynamic studies of novel phytoconstituents in an investigation of the potential inhibition of protein kinase C- beta II in diabetic neuropathyJournal of Molecular Chemistry
Medicinal Chemistry, Diabetic neuropathy, Computational biology, PKC-beta II, Hydrangenol, Phyllodulcin, Molecular Dynamic study Diabetic neuropathy, a debilitating complication of diabetes, necessitates innovative therapeutic interventions targeting Protein Kinase C-beta II (PKC-beta II). This study derives its rationale from the established antioxidant, anti-inflammatory, and hypoglycemic attributes of Piperine, Columbin, Phyllodulcin, Caftaric acid, Esculentin, and Hydrangenol. The primary…
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Molecular mechanism facets of Oxidative stress mediated pathogenesisJournal of Molecular Chemistry
Medicinal Chemistry, Oxidative stress, ulcers, aging, cardiovascular diseases, pulmonary disease, hepatic failure, diabetes, cancer, molecular mechanism, oxidation pathways Oxidative stress arises from an imbalance between reactive oxidants and the antioxidant defense system in cells. This article outlines the mechanisms and effects of oxidative stress on disease onset. Reactive oxidants, like superoxide anion and hydrogen peroxide,…
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Metal catalyzed notable organic reactions: Synthesis, mechanistic insights and applicationsJournal of Molecular Chemistry
Review Articles, Catalyst, Heteroatom bonds, organic transformations, Organic synthesis, Heck reaction, heterocyclic chemistry, C-H activation Transition metal catalysts have played an important role in forming carbon–carbon and carbon–heteroatom bonds. Formation of these bonds by using various transition metals such as Pd, Ni, Ru, Rh has been extensively investigated and documented in the literature. Recent years…
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Recent advances in Mass Spectrometry: An appraisal of fundamentals and applicationsJournal of Molecular Chemistry
Review Articles, Mass spectrometry, Analyzers, FT-ICR MS, Ionization Methods, Analytical Methods The application of mass spectrometry (MS) for structural elucidation in life sciences and bioanalytical approaches has become progressively significant. The recent advancements in MS have led to remarkable improvements in mass resolving power, mass accuracy, isotopic abundance accuracy, and accurate mass multiple-stage MS (n)…
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In silico screening and molecular docking study of quinoline based compounds with Human kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative receptor target for potential antibacterialsJournal of Molecular Chemistry
Medicinal Chemistry, Quinoline, Binding affinity, Biological activity, Antibiotic, Molecular docking, Molecular modeling, In-silico study, simulations The quinolines based drugs and its analogues are widely used as a medicinal drug. In this study, five compounds from quinoline-based pharmaceuticals have been discovered using virtual screening with Autodock software, with binding affinities ranging from 6.6 to 5.4 kcal/mol.…
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Synthetic polymer nano-film coating efficacy evaluation in prevention of chemicals induced corrosion of monumentsMaterials NanoScience
Nanochemistry & Materials Chemistry, Nanofilm, Polymer, Corrosion, Material protection, Chemistry of materials One of the most notable adverse effects of acidifying air quality is damage to materials exposed to the atmosphere. Systematic fields and laboratory experiments have been done to understand the mechanisms underlying the impacts of pollutants on the measurement of damage and estimate…
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Copper-catalyzed Click Chemistry for polyether-based dendronized multi-amphiphilic polymers and their applicationsJournal of Molecular Chemistry
Review Articles, Polyethers, Novozyme-435, click chemistry, dendronized polymers, nanocarriers Click chemistry and bio-orthogonal chemistry stands out as dynamic tools for chemists and biologists to snap together chemical entities as well as chemical and biological building blocks with just a click to construct a variety of intricate molecular structures with ease, rapidity, and selectivity. The ground-breaking…
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Imidazo[1,2] Coumarin analogues: Synthesis and antioxidant propertiesJournal of Molecular Chemistry
Organic Chemistry, Coumarin, Antioxidant, Radical scavenging activity, DPPH, Imidazobenzothiazole, Spectrophotometric study, natural products, heterocyclic chemistry, organic synthesis Two coumarin derivatives, namely 3-benzo[d]imidazo[2,1-b]thiazol-2-yl)-chromen-2-one (IBT) and 3-(8-hydroxy-imidazo[1,2-a]pyridin-2-yl)-chromen-2-one (IMPY), were synthesized and their antioxidant properties were investigated using spectrophotometric methods. The percentage of radical scavenging activity (%RSA) for each compound was determined using the α, α-diphenyl-β-picrylhydrazyl (DPPH) assay…
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Antioxidant activity of synergistic quercetin resveratrol
Journal of Molecular Chemistry Read More Keywords: item categories Polyphenols, the most prevalent and naturally occurring substances have synergistic qualities that may have positive effects on human’s health. When synergistic foods are combined, the evidence for health benefits is greater than when the foods are consumed separately. Nutrient deficiency is a well-known phenomenon in many…
